BAXIDIL SOLUBLE takes advantage of the synergism which is maximized by combining trimethoprim and sulfadiazine in a 1:5 ratio, resulting to broader spectrum of action and more effective treatment.
BAXIDIL SOLUBLE’s synergistic combination acts by inhibiting the target organism at 2 important points in their metabolism. Bacteria have to produce their own folic acid and are not able to utilize pre-formed folic acid. This gives trimethoprim-sulfadiazine a wide safety margin since animals use only pre-formed folic acid. Trimethoprim preferentially inhibits the formation of dihydrofolate reductase by acting as false substrate to the bacteria. Sulfadiazine inhibits the reduction of tetrahydrofolic acid into dihydrofolic acid, an essential step in the formation of folic acid by the bacteria. By preferentially acting on these 2 consecutive steps, bacteria cannot produce folic acid, thus resulting to their death.
SYNERGISTICS EFFECT (formulated in the ideal 1:5 trimethoprim-sulfadiazine ratio for maximum synergism resulting to broad spectrum activity, less side effects and bactericidal action)
SAFE FOR YOUNG ANIMALS(synergism significantly reduces side effects; in young animals, its bactericidal effect compensates the still underdeveloped immune system by killing the bacteria.)
FORMULATION: Per gram contains:
Sulfadiazine (Sodium), 200 mg
Trimethoprim, 40 mg
CONTRAINDICATION: Do not give to severely dehydrated animals, pregnant animals and in those suffering from renal disease.
Dosage and Administration:
· Prevention: Mix 1 tsp (3g) per gallon of water for 5-7 days.
· Treatment: Mix 2 tsp (6g) per gallon of drinking water for 5 days.
WITHDRAWAL PERIOD: 5 days